This species is closely related to both Pycnocoma cornuta and Pycnocoma angustifolia. Intermediate forms between the three species exist, indicating that they could all be part of the same species[
Pycnocoma brachystachya Pax
Pycnocoma zenkeri Pax
Pycnocoma macrophylla is a shrub growing up to 3 metres tall[
Although poisonous, the plant is sometimes gathered from the wild for local medicinal use.
The plant is very poisonous and has sometimes been used for criminal poisoning[
]. Ingestion causes immediate and prolonged intestinal shock[
Although all parts of the plant are strongly purgative, the plant has local medicinal uses[
The plant is used s a fish poison[
West tropical Africa - Cote D'Ivoire, Ghana, Nigeria, Cameroon, Gabon, DR Congo.
Undergrowth in high forest at elevations from 500 - 750 metres[
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The flowers have a strong, repellent smell[
The root bark is strongly purgative[
]. It is considered to be too strong a medicine to administer to children[
]. To stop the purging, an adult patient to whom the root has been administered is given raw [?oil-]palm nut to eat[
The stem bark is ground, mixed with water and lemon juice and drunk as an emetic[
Highly active protein kinase C-agonizing compounds were isolated from the leaves and identified as esters of the diterpenoid 11,18-dehydro-phorbol and of 4,12-dideoxy-16-hydroxy-phorbol. These phorbol derivatives stimulated the central nervous system by markedly inhibiting amphetamine-induced locomotor activity in mice[
A root extract exhibited antitumor activity in the P388 lymphocytic leukaemia test; scopoletin was found to be partly responsible for this effect[
The natural presence of the plant is held to be an indication of poor soil[
The fruits are used for tanning[
The wood is used to make boys' spinning tops[
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